Most of the sulphonylurea derivatives have poorly water soluble drugs and gliclazide belongs to this class. The antidiabetics are most widely used drugs in the treatment of diabetes mellitus. The aim of current study was to formulate immediate release tablet to solve the problem of dissolution and person to person bio variability due to its poor solubility in water. Initially gliclazide was dissolved/suspended in PEG 400 to get a clear medicated liquid, then this solution poured on carrier material (Avicel PH 102) and subjected for mixing, subsequently coating material (Aerosil 200) was added in the previous mixture. Also 2% croscarmellose was added as a disintegrant. The resulting mixture was then subjected for precompression evaluation, tabletting and post compression evaluation. The precompression evaluation results of liquisolid system showed angle of repose ranging from 23.44-38.56° and dissolution time ranging from 9 minute to 24 minute having drug 98.105-101.58 %. Selected batch showed satisfactory angle of repose and dissolution time.
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